Mana ShankaraVaraPrasad Garu is all about an NSG officer, Shankara Varaprasad (Chiranjeevi), who has a broken marriage with a wealthy woman, Sasirekha (Nayanthara). The leading lady divorces the protagonist after a few misunderstandings. The rest of the film is about how Shankara Varaprasad fixes his troubled married life.